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Home Page: Journal of Investigative Dermatology
Using congenic mapping analysis, Okumura et al. identify an SNP in the 3’ untranslated region of Pak1 that is responsible for the skin tumor modifier of MSM1a locus. In a murine skin carcinogenesis model, this SNP strongly suppresses papilloma development via a mechanism involving polyadenylation, shedding light on the role of polyadenylation in skin carcinogenesis.
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Cell signaling - Wikipedia
In biology, cell signaling (cell signalling in British English) or cell communication is the ability of a cell to receive, process, and transmit signals with its environment and with itself. Cell signaling is a fundamental property of all cellular life in prokaryotes and eukaryotes. Signals that originate from outside a cell (or extracellular signals) can be physical agents like mechanical ...
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Signal transduction - Wikipedia
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.Proteins responsible for detecting stimuli are generally termed receptors, although in some cases the term sensor is used.
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Insulin-like growth factor 1 - Wikipedia
IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. Production is stimulated by growth hormone (GH) and can be retarded by undernutrition, growth hormone insensitivity, lack of growth hormone receptors, or failures of the downstream signaling pathway post GH receptor including SHP2 and STAT5B.
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Botulinum toxin - Wikipedia
Botulinum toxin (BoNT), often shortened to Botox, is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species. It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromuscular junction, thus causing flaccid paralysis. The toxin causes the disease botulism.The toxin is also used commercially …
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Glossary | Linus Pauling Institute | Oregon State University
Adrenal glands a pair of small glands, located above the kidneys, consisting of an outer cortex and inner medulla. ... Ceramides function as signaling molecules and are critical structural components in cell membranes. Cerebral ... a hormone produced by specialized cells in the kidneys that stimulates the bone marrow to increase the production ...
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Glycoprotein - Wikipedia
Glycoproteins are proteins which contain oligosaccharide chains covalently attached to amino acid side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification.This process is known as glycosylation. Secreted extracellular proteins are often glycosylated.. In proteins that have segments extending extracellularly, the …
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Cell Signaling - The Definitive Guide | Biology Dictionary
Jan 15, 2021 · Intracellular signals are produced by the same cell that receives the signal. On the other hand, intercellular signals can travel all throughout the body. This allows certain glands within the body to produce signals which take action on many different tissues across the body. ... Signaling molecules are currently assigned one of five ...
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The Pituitary Gland and Hypothalamus | Anatomy and …
Identify the six hormones produced by the anterior lobe of the pituitary gland, their target cells, their principal actions, and their regulation by the hypothalamus ... (POMC) which produces several biologically active molecules when cleaved, including ACTH, melanocyte-stimulating hormone, and the brain opioid peptides known as endorphins ...
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JCI - FGF23 signaling impairs neutrophil recruitment and host …
Feb 15, 2016 · Besides conformational changes, integrin activation also causes clustering of these molecules. To investigate whether FGF23 also inhibits clustering of LFA-1, we performed confocal microscopy and could observe a significant decrease of IL-8–stimulated HL60 cells with clustered LFA-1 on the cell surface (Figure 4, E and F). However, this ...
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