Keyword Analysis & Research: signaling molecule irs

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What are IRS proteins?

The IRS proteins are a family of cytoplasmic adaptor proteins that transmit signals from the insulin and IGF-1 receptors to elicit a cellular response.

How does tyrosine bind to IRS-1?

Tyrosine phosphorylation of the insulin receptors or IGF-1 receptors, upon extracellular ligand binding, induces the cytoplasmic binding of IRS-1 to these receptors, through its PTB domains. Multiple tyrosine residues of IRS-1 itself are then phosphorylated by these receptors.

Does IRS-1 bind SHP-2 and negatively regulate insulin signaling?

"The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling". The Journal of Biological Chemistry. 273 (41): 26908–14. doi: 10.1074/jbc.273.41.26908.

What are signaling molecules?

Signaling molecules are the molecules that are responsible for transmitting information between cells in your body. The size, shape, and function of different types of signaling molecules can vary greatly. Some carry signals over short distances, while others transmit information over very long distances.

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