Keyword Analysis & Research: pmel cell


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What is the structure and function of PMEL?

Structure and function. PMEL is a 100 kDa type I transmembrane glycoprotein that is expressed primarily in pigment cells of the skin and eye. The transmembrane form of PMEL is modified in the secretory pathway by elaboration of N-linked oligosaccharides and addition and modification of O-linked oligosaccharides.

How is PMEL modified in the secretory pathway?

The transmembrane form of PMEL is modified in the secretory pathway by elaboration of N-linked oligosaccharides and addition and modification of O-linked oligosaccharides. It is then targeted to precursors of the pigment organelle, the melanosome, where it is proteolytically processed to several small fragments.

What does PMEL17 stand for?

"Epitope mapping of the melanosomal matrix protein gp100 (PMEL17): rapid processing in the endoplasmic reticulum and glycosylation in the early Golgi compartment." Cited for: PROTEOLYTIC PROCESSING, GLYCOSYLATION.

What is PMEL17 and tetraspanin CD63?

"Pmel17 initiates premelanosome morphogenesis within multivesicular bodies." Cited for: SUBCELLULAR LOCATION, PROTEOLYTIC PROCESSING, SUBUNIT, FUNCTION, GLYCOSYLATION. "The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis." Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CD63.

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