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PMEL airmen increase efficiency > Mountain Home Air …
Feb 03, 2016 · CEE status allows PMEL to extend the calibration interval, saving time and resources. Once a piece of equipment is needed again it can be …
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Identification of the genomic insertion site of Pmel-1 TCR
The pmel-1 T cell receptor transgenic mouse has been extensively employed as an ideal model system to study the mechanisms of tumor immunology, CD8+ T cell differentiation, autoimmunity and adoptive immunotherapy. The 'zygosity' of the transgene affects the transgene expression levels and may compro …
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People | NOAA Pacific Marine Environmental Laboratory …
PMEL Division - Any - Administration Computer and Networking Services Engineering Development Ocean Climate Ocean Environment Office of the Director Search for name(s)
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U.S. Air Force - Career Detail - Precision Measurement
Any time a piece of equipment or machinery is used, there are an infinite number of things that need to work perfectly. Responsible for calibrating equipment used in virtually every phase of maintenance, Precision Measurement Equipment Laboratory specialists ensure that every piece of equipment is in precise working order.
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PMEL - Melanocyte protein PMEL precursor - Homo …
Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody …
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PMEL (gene) - Wikipedia
PMEL cleavage is mediated by several proteases including a proprotein convertase of the furin family, a "sheddase" that might include members of the a disintegrin and metalloproteinase (ADAM) family, and additional proteases in melanosomes or their precursors.
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005023 - B6.Cg-Thy1 /Cy Tg(TcraTcrb)8Rest/J
These coinjected transgenes encode an H2-D b-restricted Valpha1 Vbeta13 T-cell receptor that recognizes a peptide comprising amino acids 25-33 of the protein known as pmel-17/gp100, a pigment biosynthetic enzyme that is encoded by the mouse Si (silver) gene and is expressed both in normal melanocytes and in malignant melanoma. The insertion is accompanied by a 157-bp …
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Metrology - Calibration - TMDE - PMEL - METCAL
For any current or former calibration, metrology, PMEL, and TMDE technicians and engineers (Both civilian and military.) This group is NOT about weather. …
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What does PMEL stand for?
View/Edit Mouse. Melanocyte protein PMEL also known as premelanosome protein (PMEL) or silver locus protein homolog (SILV) is a protein that in humans is encoded by the PMEL gene. Its gene product may be referred to as PMEL, silver, ME20, gp100 or Pmel17.
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Is there an integration site for the pmel-1 mouse?
However, the integration sites for the pmel-1 mouse have remained uncharacterized. This is also true for many other commonly used transgenic mice created before the modern era of rapid and inexpensive next-generation sequencing.
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How is PMEL modified in the secretory pathway?
The transmembrane form of PMEL is modified in the secretory pathway by elaboration of N-linked oligosaccharides and addition and modification of O-linked oligosaccharides. It is then targeted to precursors of the pigment organelle, the melanosome, where it is proteolytically processed to several small fragments.
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What is the PMEL Si transgene?
This transgenic strain carries a rearranged T cell receptor transgene specific for the mouse homologue (pmel Si or pmel-17) of human premelanosome protein (referred to as PMEL, SILV or gp100), and the T lymphocyte specific Thy1 a (Thy1.1) allele. About 1/3 of transgenic mice develop lymphomas by 5 to 7 months of age.
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