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Frequently Asked Questions

What is the structure and function of PMEL?

Structure and function. PMEL is a 100 kDa type I transmembrane glycoprotein that is expressed primarily in pigment cells of the skin and eye. The transmembrane form of PMEL is modified in the secretory pathway by elaboration of N-linked oligosaccharides and addition and modification of O-linked oligosaccharides.

Is there an integration site for the pmel-1 mouse?

However, the integration sites for the pmel-1 mouse have remained uncharacterized. This is also true for many other commonly used transgenic mice created before the modern era of rapid and inexpensive next-generation sequencing.

Is the pmel-1 T cell receptor transgenic mouse a suitable model for Immunology?

The pmel-1 T cell receptor transgenic mouse has been extensively employed as an ideal model system to study the mechanisms of tumor immunology, CD8+ T cell differentiation, autoimmunity and adoptive immunotherapy. The 'zygosity' of the transgene affects the transgene expression levels and may compromise optimal breeding scheme design.

What is the PMEL Si transgene?

This transgenic strain carries a rearranged T cell receptor transgene specific for the mouse homologue (pmel Si or pmel-17) of human premelanosome protein (referred to as PMEL, SILV or gp100), and the T lymphocyte specific Thy1 a (Thy1.1) allele. About 1/3 of transgenic mice develop lymphomas by 5 to 7 months of age.

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