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N-Nitrosodimethylamine - Wikipedia
In the laboratory, NDMA can be synthesised by the reaction of nitrous acid with dimethylamine: HONO + (CH 3 ) 2 NH → (CH 3 ) 2 NNO + H 2 O The mechanism of its carcinogenicity involves metabolic activation steps resulting in the formation of methyl diazonium, an alkylating agent .
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Technical Fact Sheet – N-Nitroso-dimethylamine …
NDMA can be unintentionally produced in and released from industrial sources through chemical reactions, such as those that involve alkylamines with nitrogen oxides, nitrous acid or nitrite salts.
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CDC - NIOSH Pocket Guide to Chemical Hazards - N
Oct 30, 2019 · NIOSH. At concentrations above the NIOSH REL, or where there is no REL, at any detectable concentration: (APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode. (APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a ...
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N-Nitrosodimethylamine (NDMA) - World Health …
N-Nitrosodimethylamine, or NDMA, can occur in drinking-water through the degradation of dimethylhydrazine (a component of rocket fuel) as well as from several other industrial processes.
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NUCON Thermal Oxidation System Performance on Hanford …
The TOS achieved target removal for NDMA at high concentration, and reduced NDMA exhaust concentration to a very low level in that test. However, it failed to reach target performance metrics for NDMA at 200% OEL. The accuracy of the ultra-trace analysis required for <50% OEL NDMA measurement is likely a factor in these results governing TOS
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Hanford Tank Vapor Assessment Report - Energy
Oct 30, 2014 · NDMA N-nitrosodimethylamine NIH National Institutes of Health NIOSH National Institute for Occupational Safety and Health NRC National Research Council OEL Occupational Exposure Limit OEL-C Occupational Exposure Limit-Ceiling ORP Office of River Protection . …
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Provisional Peer Reviewed Toxicity Values for N
l EPA/690/R-07/024F Final 6-19-2007. Provisional Peer Reviewed Toxicity Values for . N-Nitrosodimethylamine (CASRN 62-75-9) Superfund Health Risk Technical Support Center
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N-Nitrosodimethylamine | 62-75-9
The presence of N-nitrosodimethylamine (NDMA) in drinking water is most commonly associated with the chloramination of amine-based precursors. One option to control the NDMA formation is to remove the precursors via pre-oxidation, and prechlorination is among the most effective options...
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Current Occupational Exposure Limits for Ontario
The following table is a complete listing of OELs applicable to Ontario workplaces. It is a consolidation of the limits set out in the Table 1 in Regulation 833, also known as the ‘Ontario Table”, as well as applicable limits set out in the ACGIH publication, 2011 Threshold Limit Values and Biological Exposure Indices known as the “ACGIH Table” in Regulation 833.
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How is NDMA produced in a laboratory animal?
NDMA has attracted wide attention as being highly hepatotoxic and a known carcinogen in laboratory animals. Of more general concern, NDMA can be produced by water treatment by chlorination or chloramination. The question is the level at which it is produced.
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What is the formula for N-nitrosodimethylamine ( NDMA )?
N-Nitrosodimethylamine (NDMA), also known as dimethylnitrosamine (DMN), is an organic compound with the formula (CH 3) 2 NNO. It is one of the simplest members of a large class of N-nitrosamines. It is a volatile yellow oil. NDMA has attracted wide attention as being highly hepatotoxic and a known carcinogen in laboratory animals.
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What are the side effects of exposure to NDMA?
Exposure to high levels of NDMA may cause liver damage in humans (ATSDR 1999; HSDB 2012). Potential symptoms of overexposure include headache, fever, nausea, jaundice, vomiting, abdominal cramps, enlarged liver, reduced function of liver, kidneys and lungs and dizziness (HSDB 2012; O’Neil 2006).
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What is the maximum concentration of NDMA in drinking water?
The United States Environmental Protection Agency (EPA) determined that the maximal admissible concentration of NDMA in drinking water is 7 ng/L. As of July 2020, the EPA has not set a regulatory maximal contaminant level (MCL) for drinking water.
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