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Inflexal V a trivalent virosome subunit influenza vaccine
Inflexal V, a novel virosome-based trivalent influenza vaccine, has been shown to be highly immunogenic and well tolerated in children, young adults, and the elderly. Here we discuss the techniques for the manufacture of Inflexal V, highlighting the purity and consistency of the manufacturing proces …
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Inflexal®V a trivalent virosome subunit influenza vaccine
Dec 20, 2002 · Inflexal ® V, a novel virosome-based trivalent influenza vaccine, has been shown to be highly immunogenic and well tolerated in children, young adults, and the elderly. Here we discuss the techniques for the manufacture of Inflexal ® V, highlighting the purity and consistency of the manufacturing process. Key factors to be taken into account in the construction of Inflexal ® V are the ...
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Eleven years of Inflexal® V—a virosomal adjuvanted
Jul 16, 2009 · Inflexal ® V is the only virosomal adjuvanted influenza vaccine licensed for all age groups. During its 11 years on the market, Inflexal ® V has shown an excellent tolerability profile due to its biocompatibility and purity. The vaccine contains no thiomersal or formaldehyde and very low levels of …
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Inflexal V Infusion - Product - TabletWise
Sep 27, 2020 · Before using Inflexal V Infusion, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.).Some health conditions may make you more susceptible to the side-effects of the drug.
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Immunogenicity and Safety of a Single 0.5 mL Dose of
2 doses of Inflexal V influenza vaccine (surface antigen, inactivated, virosome) 2010/2011, 4 weeks apart, containing per 0.25 mL dose: 7.5 μg HA antigen of A/California/7/2009 (H1N1)-like virus 7.5 μg HA antigen of A/Perth/16/2009 (H3N2)-like virus
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An Overview of Nanocarrier-Based Adjuvants for Vaccine
Mar 27, 2021 · Similarly, Inflexal ® V is another virosome-based adjuvanted influenza vaccine licensed for all age groups (up from 6 months) that was developed by Berna Biologics Ltd., Switzerland . Inflexal ® V is composed of a haemagglutinin surface molecule of the influenza virus, which is attached to the lecithin phospholipid bilayer virosome.
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Facilitating Translational Nanomedicine via Predictive
Because of high biocompatibility of lipids, several commercial liposome-drug formulations have been developed, mostly relying on polyethylene glycol (PEG)-conjugated lipids, such as DOXIL, AmBisome, Epaxal, and Inflexal V, and are under clinical trials focusing on various types of disease treatments.
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What are the production blocks for inflexal V?
The manufacturing process for Inflexal ® V is comprised of two production blocks: purified and inactivated influenza whole-virus antigen, and the formulation of the influenza glycoprotein subunits. Particular attention is paid to confirm the complete inactivation of each seasons’ new influenza strains.
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How many doses of inflexal V have been sold?
Since the introduction to the Swiss market in 1997, Crucell (former Berna Biotech Ltd.), has sold over 41 million doses worldwide of the virosomal adjuvanted influenza vaccine, Inflexal V. Since 1992, 29 company sponsored clinical studies investigating the efficacy and safety of Inflexal V have been completed in which 3920 subjects participated.
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What makes up the virosome of inflexal V?
The actual composition of Inflexal ® V consists of a mixture of three monovalent virosome pools, each formed with one influenza strain’s specific HA and NA glycoproteins. The influenza strains chosen are dependent on the yearly recommendations of the WHO.
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