Keyword Analysis & Research: dosage anti xa apixaban


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What is the recommended dose of apixaban?

…twice daily dose is mandated in the label. The dose of apixaban is 5 mg twice daily as studied in the AUGUSTUS trial. Dose reduction of apixaban to 2.5 mg twice daily may be necessary in patients with …

How is afxaa measured in patients treated with apixaban?

Blood samples were taken to measure the trough and peak levels of AFXaA using a chromogenic anti-factor assay, as well as prothrombin time (PT) and activated partial thromboplastin time (aPTT). We also reviewed complications such as major bleeding of patients treated with apixaban.

What are the complications of apixaban?

We also reviewed complications such as major bleeding of patients treated with apixaban. In patients given a 5.0-mg apixaban dose, the median trough and peak levels of AFXaA were 104.5 and 202.0 ng/mL. In patients given a 2.5-mg apixaban dose, the median trough and peak AFXaA levels were 76.0 and 151.0 ng/mL.

How long does the anticoagulant effect of apixaban last?

The anticoagulant effect of apixaban can be expected to persist for at least 24 hours after the last dose (i.e., about two half-lives). An agent to reverse the anti-factor Xa activity of apixaban is available. Please visit www.andexxa.com for more information on availability of a reversal agent.

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