Keyword Analysis & Research: apixaban iv

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Frequently Asked Questions

What is apixaban and how does it work?

What is apixaban? Apixaban is used to lower the risk of stroke caused by a blood clot in people with a heart rhythm disorder called atrial fibrillation. Apixaban is also used after hip or knee replacement surgery to prevent a type of blood clot called deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism).

What anticoagulants should be given with apixaban?

b) Begin both a parenteral anticoagulant (LMWH/fondaparinux or UFH) and warfarin at the same time that the next dose of apixaban would have been given

When should apixaban be taken with CYP3A4 inhibitors?

If taking apixaban dose >2.5 mg BID, decrease dose by 50% if coadministered with strong dual inhibitors of CYP3A4 and P-gp; if currently taking apixaban 2.5 mg PO BID, avoid coadministration with strong dual inhibitors of CYP3A4 and P-gp

What is the highest dose of apixaban?

The dose-proportionality analysis showed that apixaban exposure increased proportionally to dose across the approved dose range (2.5–10 mg) [34]. Exposure was less than proportional for doses greater than 10 mg; this appeared to be driven by the less-than-proportional increases in exposure following administration of the 25- and 50-mg doses.

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