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RCSB PDB - 6CR1: adalimumab EFab
Mar 16, 2018 · We report its effect on the biophysical properties of an antibody and the crystal structure of the EFab domain substituted into the adalimumab Fab (PDB ID 6CR1). Organizational Affiliation : …
DA: 41 PA: 18 MOZ Rank: 25
RCSB PDB - 4NYL: Crystal structure of adalimumab FAB fragment
Dec 10, 2013 · As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can …
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4NYL: Crystal Structure Of Adalimumab Fab Fragment
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 …
DA: 25 PA: 9 MOZ Rank: 72
RCSB PDB - 3WD5: Crystal structure of TNFalpha in complex
Jun 06, 2013 · As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can …
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What kind of disease is adalimumab used for?
Adalimumab is a subcutaneously administered biological disease modifier for the treatment of rheumatoid arthritis and other chronic debilitating diseases mediated by tumor necrosis factor 2, 3. It was originally launched by Abbvie in the U.S. and approved in 2002 by the FDA 1. This drug is frequently known as Humira.
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When was adalimumab first approved by the FDA?
It was originally launched by Abbvie in the U.S. and approved in 2002 by the FDA 1. This drug is frequently known as Humira. It is produced by recombinant DNA technology using a mammalian cell expression system.
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How long does adalimumab stay in the body?
Adalimumab concentrations in the synovial fluid from five rheumatoid arthritis patients ranged from 31-96% of those in serum 12. Most likely removed by opsonization via the reticuloendothelial system 7. The mean terminal half-life was approximately 2 weeks, ranging from 10 to 20 days across studies 12.
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What happens when Adalimumab is combined with alfentanil?
The metabolism of Alfentanil can be increased when combined with Adalimumab. The risk or severity of adverse effects can be increased when Adalimumab is combined with Alirocumab. The metabolism of Almotriptan can be increased when combined with Adalimumab. The metabolism of Alogliptin can be increased when combined with Adalimumab.
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