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Anti-Human TNF alpha (Adalimumab) - Fc Muted™ - Leinco
FC The suggested concentration for Adalimumab biosimilar antibody for staining cells in flow cytometry is ≤ 0.25 μg per 10 6 cells in a volume of 100 μl. Titration of the reagent is recommended for optimal …
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Methotrexate Reduces the Clearance of Adalimumab by
The FcRn concentration in tissues and the PK parameters of adalimumab were compared between MTX-treated and placebo groups. Results: In rats with normally functioning FcRn, the concentrations of FcRn were significantly increased in the liver (F=105.5, p=0.000) and kidney (F=996.312, p=0.000) after treatment with MTX, and the clearance (CL/F) of adalimumab …
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Fcγ receptor 3B polymorphism is associated with
The FCGR3B NA1/NA1 genotype is associated with hypersensitivity reactions to adalimumab.
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Real-life utility and diagnostic accuracy of a home
Aims: The home-performed fecal calprotectin (FC) test has been proposed for the remote management of inflammatory bowel disease (IBD) patients. We present our real-world experience on the use of FC home testing in IBD patients under maintenance treatment with adalimumab.
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How are adalimumab and TNF-α similar?
In addition to its action on TNF-α, adalimumab has an Fc portion that has the ability to bind to cell surface Fc gamma receptors (FcγRs) which may affect its serum half-life and certain innate and adaptive immune responses such as antibody-dependent cell cytotoxicity and complement activation.
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How does adalimumab work to treat autoimmune disease?
Adalimumab is a TNF-inhibiting, anti-inflammatory, biologic medication. It binds to tumor necrosis factor-alpha (TNFα), which normally binds to TNFα receptors, leading to the inflammatory response of autoimmune diseases. By binding to TNFα, adalimumab reduces this inflammatory response.
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Are there any side effects to taking adalimumab?
Each of the ACR core criteria significantly improved with each adalimumab dose. Adalimumab generally was well tolerated, with most adverse events being mild or moderate.
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When was adalimumab approved for use in ulcerative colitis?
Although only approved for ulcerative colitis from late 2012, by the FDA in the disease's management, it had been used for several years in cases that have not responded to conventional treatment at standard dosing for Crohn's disease. Adalimumab, sold under the brand name Humira, was approved for use in the United States in 2002.
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